Mihir Kekre

Operations Lead - Next Generation Sequencing

mihir.kekre@cgps.group

Supports the assembly of cost-effective genomics-powered clinical research laboratories with an eventual focus of scaling them for actionable national public health.

Learn more about my work

As the NGS Ops Lead for our NIHR Global Health Research Unit, Mihir is responsible for the delivery of projects in Africa, Asia and South America focused on lab asset creation, comprehensive hands-on training and sustainability of long-term operations, often in resource-limited settings.

Mihir has extensive experience designing, automating and scaling fully-functional labs centred around next generation genome sequencing. Previously, he has led the development and maturation of Wellcome Sanger's largest product line (WGS and Genotyping) within the Institute's commercial core.

Publications

Course Trainer / Developer:

Train the Trainer: Capacity building for genomic surveillance of AMR in low- and middle-income countries. Wellcome Genome Campus, UK. Find out more.

Publications:

Whole-Genome Sequencing as Part of National and International Surveillance Programmes for Antimicrobial Resistance: A Roadmap, BMJ Global Health (2020).

Development of copy number assays for detection and surveillance of piperaquine resistance associated plasmepsin 2/3 copy number variation in Plasmodium falciparum, Malaria Journal (2020).

Mapping imported malaria in Bangladesh using parasite genetic and human mobility data, ELife (2019).

Population genomics of Plasmodium vivax, **Nature Genetics **(2017)

Rate, spectrum and genome-wide distribution of spontaneous mitotic mutation in the malaria parasite Plasmodium falciparum, _Nucleic Acids Research _(2016).

Whole genome sequencing of the malaria parasite Plasmodium falciparum from dried blood spots using selective whole genome amplification, Malaria Journal (2016).

Genomic epidemiology of Artemisinin-resistant malaria, ELife (2016).

Generation of Antigenic Diversity in Plasmodium falciparum by Structured Rearrangement of var Genes During Mitosis, PLoS Genetics (2015).

K13-Propeller Polymorphisms in Plasmodium falciparum parasites from Sub-Saharan Africa, Journal of Infectious Disease (2014).

Optimized Whole-Genome Amplification Strategy for Extremely AT-Biased Template, DNA Research (2014).